Succinic Dihydrazide

Introduction

CAS No. :	4146-43-4	MDL No. :	MFCD00007613
Formula :	C4H10N4O2	Boiling Point :	No data available
Linear Structure Formula :	(CH2C(O)NHNH2)2	InChI Key :	HCOMFAYPHBFMKU-UHFFFAOYSA-N
M.W :	146.15	Pubchem ID :	72491
Synonyms :

Physicochemical Properties

Num. heavy atoms :	10
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.5
Num. rotatable bonds :	5
Num. H-bond acceptors :	4.0
Num. H-bond donors :	4.0
Molar Refractivity :	32.76
TPSA :	110.24 Ų

Pharmacokinetics

GI absorption :	Low
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-9.16 cm/s

Lipophilicity

Log Po/w (iLOGP) :	-0.42
Log Po/w (XLOGP3) :	-2.77
Log Po/w (WLOGP) :	-2.25
Log Po/w (MLOGP) :	-1.37
Log Po/w (SILICOS-IT) :	-2.36
Consensus Log Po/w :	-1.83

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	3.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	1.33
Solubility :	3120.0 mg/ml ; 21.3 mol/l
Class :	Highly soluble
Log S (Ali) :	1.01
Solubility :	1490.0 mg/ml ; 10.2 mol/l
Class :	Highly soluble
Log S (SILICOS-IT) :	0.05
Solubility :	164.0 mg/ml ; 1.12 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	2.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.55

Signal Word:	Danger	Class:	4.1
Precautionary Statements:	P210-P240-P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362-P370+P378-P403+P233-P501	UN#:	1325
Hazard Statements:	H228-H302-H315-H319-H335	Packing Group:	Ⅱ
GHS Pictogram:

Related View all 

• 

  Ghk-Cu

• 

  Gly-His-Lys acetate salt

• 

  N-Phenylacetyl-L-Prolylglycine ethyl ester

• 

  L-Phenylalanyl-L-isoleucine

• 

  L-Isoleucyl-L-phenylalanine

• 

  L-Ala-L-phe

• 

  L-Glutathione Reduced

• 

  L-Alanyl-L-tyrosine