4-Bromo-2-chlorobenzoic acid

Introduction

CAS No. :	59748-90-2	MDL No. :	MFCD00040903
Formula :	C7H4BrClO2	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	JAVZWSOFJKYSDY-UHFFFAOYSA-N
M.W :	235.46	Pubchem ID :	108829
Synonyms :

Physicochemical Properties

Num. heavy atoms :	11
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.0
Num. rotatable bonds :	1
Num. H-bond acceptors :	2.0
Num. H-bond donors :	1.0
Molar Refractivity :	46.11
TPSA :	37.3 Ų

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.82 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.68
Log Po/w (XLOGP3) :	2.7
Log Po/w (WLOGP) :	2.8
Log Po/w (MLOGP) :	2.94
Log Po/w (SILICOS-IT) :	2.54
Consensus Log Po/w :	2.53

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.56

Water Solubility

Log S (ESOL) :	-3.34
Solubility :	0.108 mg/ml ; 0.000459 mol/l
Class :	Soluble
Log S (Ali) :	-3.14
Solubility :	0.172 mg/ml ; 0.000731 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.25
Solubility :	0.134 mg/ml ; 0.000568 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.42

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P305+P351+P338	UN#:
Hazard Statements:	H302-H315-H319-H335	Packing Group:
GHS Pictogram:

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