14691-89-5 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl

Introduction

CAS No. :	14691-89-5	MDL No. :	MFCD00043593
Formula :	C11H21N2O2	Boiling Point :	No data available
Linear Structure Formula :	-	InChI Key :	-
M.W :	213.30	Pubchem ID :	-
Synonyms :

Physicochemical Properties

Num. heavy atoms :	15
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.91
Num. rotatable bonds :	2
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	62.4
TPSA :	32.34 Ų

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-7.23 cm/s

Lipophilicity

Log Po/w (iLOGP) :	-3.76
Log Po/w (XLOGP3) :	0.52
Log Po/w (WLOGP) :	1.11
Log Po/w (MLOGP) :	1.15
Log Po/w (SILICOS-IT) :	0.59
Consensus Log Po/w :	-0.08

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.36
Solubility :	9.35 mg/ml ; 0.0438 mol/l
Class :	Very soluble
Log S (Ali) :	-0.77
Solubility :	36.2 mg/ml ; 0.17 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.72
Solubility :	4.06 mg/ml ; 0.0191 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.04

Signal Word:	Warning	Class:
Precautionary Statements:	P305+P351+P338	UN#:
Hazard Statements:	H302-H319	Packing Group:
GHS Pictogram:

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