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Zibo Qipeptide Biotechnology Co., Ltd

Zinc carnosine is a synthesized form of carnosine originallydiscovered in Japan and formed by chelating zinc to carnosine in aone-to-one ratio giving

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Basic information

CAS No. 107667-60-7
Synonyms Zinc, [β-alanyl-κN-L-histidinato(2-)-κN,κO]-;Zinc, [N-β-alanyl-L-histidinato(2-)-N,NN,Oα]-; L-Histidine, N-β-alanyl-, zinc complex;Z 103;Zinc L-carnosine;Polaprezinc; β-Alanyl-L-histidinato zinc;Promac; Promac (antiulcer agent)
Molecular Formula
Molecular Weight C9H12N4O3Zn
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More Basic view


Zinc carnosine is a molecule that’s made by binding a zinc ion to l-carnosine, an amino acid. This complex doesn’t exist in a natural form and has been developed in pharmaceutical laboratories to treat stomach ulcers and gastrointestinal disorders.


The unique ionic structure of the zinc l-carnosine complex has potent effects on intestinal health and stimulates gut repair processes. 


Taking a zinc carnosine supplement is significantly more effective in supporting gut health than elemental zinc supplementation alone.


The gastric mucosa, or mucous membrane, plays a crucial role in gastrointestinal health. 


It's the innermost layer of the intestinal lining that covers almost all parts of the gastrointestinal tract, including the esophagus, stomach, small intestines, and large bowel. 


The mucosal layer plays a vital role in the digestion and absorption of nutrients, protects the gut from the harsh acidity of stomach acid and invading microbes, and prevents digestive enzymes from breaking down intestinal tissue. 


However, alcohol, bacterial infections, stress, and medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics, and steroids can damage gastric mucosal cells, which impairs normal gut function and can trigger various gastrointestinal disorders. 


Zinc carnosine has been found to readily enter gastric epithelial cells and promotes the regeneration of damaged cells, which explains why this zinc complex has such potent gut healing properties.


Here are seven ways zinc carnosine benefits gut health.


1. Promotes healthy gut mucus

Zinc, an essential mineral, has long been known to support a healthy intestinal lining, and these beneficial effects are amplified when combined with l-carnosine.


Zinc carnosine readily enters mucosal cells, where it stimulates mucin production. Mucins are proteins that make up the protective mucus layer in the gastrointestinal tract which serves as a first-line defense barrier against harmful pathogens, chemicals, and other environmental toxins.


2. Gastric ulcers

Zinc carnosine may be particularly beneficial for individuals prone to stomach ulcers.


Research published in Nutrients found that zinc carnosine reduces intestinal inflammation and stimulates the regeneration of the gastric mucosa, a crucial step in the healing of a gastric ulcer.


“Taking zinc carnosine can lower the risk of Helicobacter pylori, a pathogenic bacteria that can survive the acidity of stomach acid,” explains Dr. Berg. “H. pylori triggers local inflammation within the gastric lining and is linked to an increased risk of developing a gastric ulcer.” 


3. Gastroesophageal reflux disease

Gastroesophageal reflux disease (GERD) is characterized by the backflow of stomach acid into the esophagus.


Zinc carnosine may help maintain the integrity of the esophageal mucosal lining and reduces the tissue damage caused by stomach acid reflux.


In addition, taking zinc carnosine has been found to maintain normal stomach acid secretion, which may reduce excessive acid production and alleviate GERD symptoms such as heartburn and acid reflux.

4. Inflammatory bowel disease

Inflammatory bowel disease (IBD) includes inflammatory conditions such as Crohn's disease and ulcerative colitis. 


Zinc carnosine has shown promising therapeutic effects in the management of IBD by lowering intestinal inflammation and supporting the regeneration of intestinal mucosal cells. 


Zinc also strengthens the gut’s immune defenses, and there is evidence that a zinc deficiency can significantly increase the risk of developing IBD. 


5. Gastrointestinal permeability 

The intestinal layer is a sophisticated structure that allows nutrients to enter the circulation while providing a barrier to harmful pathogens and toxins.


However, this barrier can become damaged and inflamed, allowing unwanted molecules to enter the body, a condition also known as intestinal permeability or leaky gut, which can trigger immune responses and inflammation within intestinal tissue.


Zinc carnosine can prevent and even reverse intestinal permeability by reducing inflammation and promoting the secretion of mucus which forms a protective barrier within the small intestines. 


6. Gastrointestinal Inflammation 

Gastrointestinal inflammation plays a significant factor in the development of ulcers, intestinal permeability, colon cancer, and IBD.


Zinc carnosine has powerful anti-inflammatory properties that inhibit the production of proinflammatory molecules while, at the same time, stimulating immune cells within the intestinal layer to secrete potent anti-inflammatory compounds.  


7. Speeds up gastrointestinal wound healing 

Taking zinc carnosine promotes the wound healing of external wounds and helps to repair damaged intestinal tissue. 


Zinc carnosine regulates the proliferation and migration of several cell types involved in wound healing, such as fibroblasts and epithelial cells, and enhances collagen synthesis, an essential structural component that repairs damaged tissues.


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1. What makes your Polaprezinc products unique?
As a leading Polaprezinc manufacturer and supplier from China, our products stand out for their high quality and composition.

2. Can you supply bulk quantities for businesses?
Yes, we are a B2B supplier of Polaprezinc, specializing in bulk Polaprezinc powder and isolate. As a premium Polaprezinc isolate supplier and wholesaler, we can meet large-scale demands efficiently.

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Absolutely. Our Polaprezinc, free from major allergens. This makes it an ideal choice for vegans and those with dietary restrictions.

4. How do you ensure the quality of your Polaprezinc products?
We adhere to strict ISO22000 & quality control standards. Being a high-quality Polaprezinc manufacturer, we ensure that every batch of Polaprezinc, whether isolate, peptide, meets the highest quality standards.

5. Do you offer Polaprezinc for international clients?
Yes, as a Polaprezinc exporter from China, we provide Polaprezinc products globally, including Polaprezinc peptide and isolate. Our efficient distribution network ensures timely delivery worldwide.

6. Are your products cost-effective for wholesale purchase?
Certainly. We pride ourselves on being an affordable Polaprezinc manufacturer, offering the best Polaprezinc prices for wholesale and bulk purchases.

7. Can I get a customized Polaprezinc formulation?
Yes, our R&D team can work with you to create a custom formulation, making us a natural Polaprezinc peptide supplier that caters to specific client needs.

8. What is the advantage of choosing your Polaprezinc isolate?
Our pure Polaprezinc isolate is of premium quality, ensuring content and excellent solubility, making it a preferred choice for various applications.

9. How do you support business customers in the Polaprezinc market?
We offer comprehensive support, including 24/7 customer service, and are a reliable Polaprezinc raw material producer. Our expertise as a Polaprezinc peptide exporter also benefits businesses looking for high-grade products.

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