| Synonyms | |
| Sequence | The synthetic peptide used to raise the antibody Cat. No. 250912 is selected from a sequence within the N-term region of mouse WNK4. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended. |
| Molecular Formula | C64H89N13O21 |
| Molecular Weight | 1375.6 g/mol |
| Purity | Purity > 80% by HPLC |
| Format | Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect. |
| Solubility | Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile. |
| Storage | Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. |
| description | ser/thr-protein kinase wnk4 regulates the activity of the thiazide-sensitive na-cl cotransporter slc12a3 by phosphorylation, which prevents membrane trafficking of slc12a3. wnk4 also inhibits the renal potassium channel kcnj1 via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. wnk4 acts as a molecular switch that can vary the balance between nacl reabsorption and k+ secretion to maintain integrated homeostasis. wnk4 is exclusively present in intercellular junctions in th edistal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. defects in wnk4 are a cause of pseudohypoaldosteronism type ii (phaii). |
How to place a order：
1) Contact us at: Service@apichina.com ;2) Provide us peptides information including Sequence, Purity, Quantity and modification(If necessary, we agree to sign confidential agreement with you before you provide these information), we will make you a quotes within 30 minutes;
3) Place us a purchaser order, we can send you a sales contract too if you need;
4) Start synthesis, and we will inform you the updates of synthesis in time;
5) Arrange shippment, HPLC analysis, MS spectrum will be shipped along the peptides too;
6) Refund all pre-payment(if pre-pay us) if we failed to synthesize any of them;
7) After-sale service: Contact us anytime if you have any problem when you use the peptides, and we will reply you as soon as possible.