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Palmitoyl pentapeptide-4

Palmitoyl Pentapeptide-4 Helps to prevent fine lines induced by repeated facial movements along with increasing the collagen and elastin matrix. Palmitoyl Pentapeptide-4 is Recommended for anti-aging, anti-wrinkle skin care and eye care products.

Molecular Formula
Molecular Weight
PubChem CID
MDL Number
Merck Index

Chemical Properties

Density 1.147 g/cm3 Boiling point 1120.1°C at 760 mmHg
Melting point Refractive index
Flash point 631.2±34.3 °C Optical Activity
Water solubility Physical State
Purity Appearance
InChI InChI=1S/C39H75N7O10/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-23-32(50)42-29(21-17-19-24-40)36(52)45-34(28(3)49)38(54)46-33(27(2)48)37(53)43-30(22-18-20-25-41)35(51)44-31(26-47)39(55)56/h27-31,33-34,47-49H,4-26,40-41H2,1-3H3,(H,42,50)(H,43,53)(H,44,51)(H,45,52)(H,46,54)(H,55,56)/t27-,28-,29+,30+,31+,33+,34+/m1/s1
Synonyms PalMitoyl Pentapeptide-4;PALMITOYL;Palmitoyl Pentapeptide-4/3;Pla-KTTKS;palmitoyl-KTTKS;Matrixyl(PAL-KTTKS);Rejuvenation peptide;Matrixyl 3000 powder;almitoyl pentapeptide;Matrixylacetate
Solubility data

Biological Description

Ki Data
pK Values 2.98±0.10(Predicted) Storage 2-8°C(protect from light)
Sequence(single) palmitoyl-Lys-Thr-Thr-Lys-Ser-OH
In Vitro
In Vivo


Application Myristoyl pentapeptide-4 is polypeptide used in masks for skin and muscles of face. Also, used in anti-wrinkle and firming facial cleanser.

Security information

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Safety Description


Cosmetic polypeptides can penetrate the dermis to increase the level of collagen and reverse the aging process of the skin through rebuilding from inside to outside.
Cosmetic pentapeptide(Palmitoyl Pentapeptide) is also a cosmetic polypeptide. The prototype of the polypeptide is palmitic acid pentapeptide, commonly known as the five peptides, being able to simulate the paralysis effect of botulinum toxin. It is a short peptide fragment consisting of five amino acids formed by peptide bonds with its structure being similar to the protein. However, the protein has a longer peptide chain, usually consisting of hundreds of amino acids. based on the differences of the number of amino acids, these polypeptides are divided into dipeptides (including two amino acids), tripeptides (including three amino acids), tetrapeptides (including four amino acids), etc. Because of the different categories of amino acids contained, both dipeptides and tripeptides have different varieties. At the same time, even with the same number of amino acids, the dipeptides will still have different varieties due to the different sort order of the amino acid. This leads to a number of peptides with a variety of roles and names. The pentapeptide is composed of six amino acids (Pal palmitic acid, Lys-lysine, Thr-threonine, Thr-threonine, Lys-lysine and Ser-serine).

The Palmitoyl Pentapeptide is actually the C-terminal fragment of Collagen I, having an effect being similar to that of the laser surgery. It can stimulate the growth of collagen, stretch fibers and hyaluronic acid, improve skin moisture and the degree of locking water, increase skin thickness and reduce the microgroove; at the same time, addition of a long chain of fatty acids (palmitic acid) can increase the absorption effect. Compared with the laser surgery, the five-peptides is equivalent to intimate fusion with the skin, changing the skin ecology and cell repair, further playing the role of intracellular hormones and enzymes.

What is Palmitoyl Pentapeptide-4?

Palmitoyl pentapeptide-4 is a type of peptide that is used in many anti-aging skincare products. It is a synthetic peptide that is derived from a naturally occurring peptide called procollagen type I. Procollagen type I is a precursor to collagen, which is a protein that gives our skin its structure and elasticity.Our bodies produce less collagen, which can lead to the development of fine lines and wrinkles Palmitoyl pentapeptide-4 is designed to stimulate the production of collagen, which helps to improve the appearance of fine lines and wrinkles and restore the skin's firmness and elasticity.Palmitoyl pentapeptide-4 is also known to help improve the skin's texture and tone, leaving it looking smoother and more radiant.


How does it work?

Palmitoyl Pentapeptide-4 works by signaling the skin to produce more collagen. Collagen is the main structural protein in the skin, responsible for its strength, elasticity, and firmness. As we age, collagen production slows down, leading to the formation of wrinkles, fine lines, and sagging skin. Palmitoyl Pentapeptide-4 mimics the activity of the body's natural peptides and stimulates collagen synthesis, helping to restore skin's firmness and elasticity.

When Palmitoyl pentapeptide-4 is applied to the skin, it penetrates the outer layer and reaches the deeper layers where collagen is produced. It then stimulates the production of collagen, which helps to firm up the skin, reduce the appearance of fine lines and wrinkles, and improve skin texture and tone. Matrixyl has been shown to be effective in clinical studies, with one study showing a 117% increase in collagen production after just 2 weeks of use. 

In addition to collagen production, Palmitoyl Pentapeptide-4 also stimulates the production of hyaluronic acid, which helps to hydrate the skin and maintain its moisture balance. It also helps to prevent the breakdown of elastin, another key component of the skin matrix that helps to maintain its elasticity.

What are the benefits of Palmitoyl Pentapeptide-4? 

Palmitoyl Pentapeptide-4 has been shown to have a range of anti-aging benefits. Here are some of the most significant benefits:

Reduces wrinkles and fine lines: Palmitoyl Pentapeptide-4 has been shown to reduce the depth and length of wrinkles and fine lines, making skin look smoother and more youthful. 

Increases firmness and elasticity: By stimulating collagen and elastin production, Palmitoyl Pentapeptide-4 helps to improve skin firmness and elasticity, giving it a more youthful appearance. 

Improves skin texture and tone: Palmitoyl Pentapeptide-4 can help to improve skin texture and tone by stimulating the production of key components of the skin matrix, resulting in smoother, more even-looking skin.

Hydrates the skin: Palmitoyl Pentapeptide-4 helps to increase the production of hyaluronic acid, a natural moisturizer that helps to keep skin hydrated and looking plump.

Protects against sun damage: Palmitoyl Pentapeptide-4 has been shown to help protect the skin against sun damage, which can cause premature aging and skin cancer.

Palmitoyl Pentapeptide-4 is typically found in serums, moisturizers, and eye creams. It is often combined with other anti-aging ingredients, such as antioxidants and hyaluronic acid, to provide even greater benefits for the skin. When used regularly, products containing Palmitoyl Pentapeptide-4 can help to reduce the appearance of fine lines and wrinkles, improve skin texture and tone, and give the skin a more youthful and radiant appearance.


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